Neurodevelopmental and behavioral effects of nonylphenol exposure during gestational and breastfeeding period on F1 rats - Université catholique de l'Ouest
Article Dans Une Revue NeuroToxicology Année : 2014

Neurodevelopmental and behavioral effects of nonylphenol exposure during gestational and breastfeeding period on F1 rats

Résumé

Nonylphenols (NP) are endocrine-disruptors known to be widely present in our environment. This studyevaluated the effects of 4-n-NP on neurobehavioral development and memory capacity after perinatalexposure on the offspring rats. Dams were gavaged with 4-n-NP (0, 50 and 200 mg/kg/day) fromgestational day 5 to postnatal day (PND) 21. Dams exposed to the higher dose lost weight duringgestation and had a longer gestational duration. Juvenile female pups of the 200 mg 4-n-NP/kg/daygroup were lighter. Their thyroid somatic index (TSI) was also affected. For male pups, a decrease of TSI atweaning for the 200 mg 4-n-NP/kg/day group and an increase of GSI for the 50 mg 4-n-NP/kg/day groupwere observed. Physical maturation (incisives and eyes) were likewise affected. In open field (OF) tests,females were more active than males. In the first OF (PND 36), a treatment effect was observed only formales, particularly for the high dose group, which became as active as females. The second OF (PND 71)showed few differences between groups (treated vs control), the gender difference whatever the dosewas not abolished. In the Morris Water Maze test, the study of the first 30 s showed that females(200 mg/kg/day) were mainly affected. Their performances were improved by 4-n-NP. These effectswere particularly important for the first short-term memory test and observed to a lesser extent in thesecond evaluation of the long-term memory (PND 69). These data showed that perinatal 4-n-NPexposure induced behavioral and neuro-developmental impairments from 50 mg/kg/day.
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Dates et versions

hal-04654558 , version 1 (19-07-2024)

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Citer

Mickaël Couderc, Allison Gandar, Abderrahmane Kamari, Yohann Allain, Aurore Zalouk-Vergnoux, et al.. Neurodevelopmental and behavioral effects of nonylphenol exposure during gestational and breastfeeding period on F1 rats. NeuroToxicology, 2014, 44, pp.237-249. ⟨10.1016/j.neuro.2014.07.002⟩. ⟨hal-04654558⟩
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