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                <forename type="first">Pierre-Yves</forename>
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                <forename>Antoine</forename>
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              <date type="whenSubmitted">2025-03-06 11:42:50</date>
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            <idno type="halRefHtml">&lt;i&gt;Clinical Kidney Journal&lt;/i&gt;, 2025, &lt;a target="_blank" href="https://dx.doi.org/10.1093/ckj/sfaf036"&gt;&amp;#x27E8;10.1093/ckj/sfaf036&amp;#x27E9;&lt;/a&gt;</idno>
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            <idno type="stamp" n="UNAM">l'unam - université nantes angers le mans</idno>
            <idno type="stamp" n="UCO">Université Catholique de l'Ouest</idno>
            <idno type="stamp" n="UCO-SCIENCES-APCOSS" corresp="UCO">Equipe APCOSS</idno>
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                <title xml:lang="en">Quality matters: chronic kidney disease progression is associated to reduced muscle strength independently of changes in skeletal muscle mass: an observational study</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Antoine</forename>
                    <surname>Chatrenet</surname>
                  </persName>
                  <email type="md5">5a8aa15a385381ec683b77108e7eda6c</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">antoine-chatrenet</idno>
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                  <persName>
                    <forename type="first">Pierre-Yves</forename>
                    <surname>de Müllenheim</surname>
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                  <email type="md5">9723f1d8a141002b6acce12bfaa00aca</email>
                  <email type="domain">uco.fr</email>
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                  <affiliation ref="#struct-1065852"/>
                  <affiliation ref="#struct-536158"/>
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                <author role="aut">
                  <persName>
                    <forename type="first">Massimo</forename>
                    <surname>Torreggiani</surname>
                  </persName>
                  <email type="md5">3976978720499d237fc691576637b19a</email>
                  <email type="domain">ch-lemans.fr</email>
                  <idno type="idhal" notation="numeric">1503686</idno>
                  <idno type="halauthorid" notation="string">2029415-1503686</idno>
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                  <persName>
                    <forename type="first">Julia Nava</forename>
                    <surname>Hernández</surname>
                  </persName>
                  <idno type="halauthorid">3405410-0</idno>
                  <affiliation ref="#struct-1223551"/>
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                <author role="aut">
                  <persName>
                    <forename type="first">Rocío Urbina</forename>
                    <surname>Arronte</surname>
                  </persName>
                  <idno type="halauthorid">3405411-0</idno>
                  <affiliation ref="#struct-1223551"/>
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                <author role="aut">
                  <persName>
                    <forename type="first">Abril Gutiérrez</forename>
                    <surname>Espinoza</surname>
                  </persName>
                  <idno type="halauthorid">3405412-0</idno>
                  <affiliation ref="#struct-1223551"/>
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                <author role="aut">
                  <persName>
                    <forename type="first">Giorgina Barbara</forename>
                    <surname>Piccoli</surname>
                  </persName>
                  <email type="md5">f2a496adddf753d411ca62fa8ed65951</email>
                  <email type="domain">ch-lemans.fr</email>
                  <idno type="idhal" notation="numeric">1503687</idno>
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                <idno type="issn">2048-8505</idno>
                <idno type="eissn">2048-8513</idno>
                <title level="j">Clinical Kidney Journal</title>
                <imprint>
                  <publisher>Oxford University Press</publisher>
                  <date type="datePub">2025-02-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/ckj/sfaf036</idno>
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              <classCode scheme="halDomain" n="sdv.mhep.un">Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.phy">Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]</classCode>
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              <p>Background and hypothesis Chronic kidney disease (CKD) is commonly associated with multifactorial neuromuscular impairments. Few studies have investigated CKD-induced changes in maximal voluntary force (MVF), and even fewer have longitudinal follow-up. The aim of this study is to investigate whether CKD progression modifies the relationship between skeletal muscle mass and force and the prevalence of sarcopenia and sarcopenic obesity. Methods The data used were prospectively collected during routine check-ups in a network of nutritional centres in Mexico and retrospectively analysed. From a dataset of 5430 patients, we selected 1098 patients with available anthropometric, kidney function, handgrip and bioimpedance data. The relationship between appendicular skeletal muscle mass (ASM) and MVF was investigated using mixed models and adjusted for age, sex, BMI, physical activity level and CKD aetiology. Sarcopenia prevalence were tested across period of follow-up using the Cochran-Mantel-Haenzen for repeated measures and across CKD stages using the Chi-2 test. Results After normalization with ASM, MVF was higher in CKD G1-G3 compared to G4 and G5 (p ≤ 0.001, Cohen's d = 0.270–0.576). Slopes between MVF and ASM were lower in CKD G3, G4 and G5 than in CKD G1-G2 (-2.268 [-3.927,-0.609], p = 0.008; -2.694 [-4.593,-0.794], p = 0.006; -3.675 [-5.326,-1.725], p &amp;lt; 0.001, respectively). The prevalence of sarcopenia and sarcopenic obesity did not differ across CKD stages, but recovery was most commonly observed in CKD G1-G2. Slope analysis showed an independent interaction between the slopes of kidney function and ASM on MVF evolution over time. Conclusions CKD negatively, progressively and independently affects the neuromuscular system, and force production is reduced for any given muscle mass as CKD progresses. While no association was found between CKD stage and prevalence of sarcopenia, recovery was more frequent in the early CKD stages. These results suggest the importance of early rehabilitation programs to improve musculoskeletal health, quality of life and survival in CKD patients.</p>
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